Rams vs 49ers Odds, Lines, Picks, and Predictions for Week 10 Monday Night Football

Cooper Kupp running with football

Los Angeles Rams wide receiver Cooper Kupp in isolated action during the second half of an NFL football game against the Tennessee Titans, Sunday, Nov. 7, 2021, in Inglewood, Calif. (AP Photo/Marcio Jose Sanchez)

  • The LA Rams take their perfect 4-0 road record to San Francisco vs the 49ers on MNF
  • Monday Betting Record: 0-0 ML; 3-5 ATS; 2-1 O/U; -1.46 units
  • Read below for odds, analysis and a betting prediction

There’s few teams in the NFL that would welcome a meeting with the Los Angeles Rams.

For the San Francisco 49ers, it may be the jumpstart they need to salvage a season that is teetering on disaster.

The Niners host the Rams on Monday Night Football, looking for their fifth straight win in this head-to-head between NFC West rivals.

Los Angeles, meanwhile, may be incorporating two of their latest shiny, new additions to a cast built to win now.

Kickoff from Levi’s Stadium goes at 8:15pm ET, and the game can be watched live on ESPN. San Francisco is currently a 3.5-point home favorite.

Rams vs 49ers Odds

Team Moneyline Spread Total
Los Angeles Rams -180 -3.5 (-105) O 50 (-110)
San Francisco 49ers +155 +3.5 (-115) U 50 (-110)

Odds as of Nov 14th at DraftKings.

Rams vs 49ers Injury Report

The biggest news this week out of Los Angeles was the team signing free agent receiver Odell Beckham Jr, who was released by the Browns.

The move originally signified another “so Rams” move of plucking star talent to win now, but it was later determined that OBJ was a necessity after receiver Robert Woods tore his ACL in practice, and is done for the year.

LA’s other prized pickup, Von Miller (ankle), is questionable to make his Rams’ debut, to pair with Aaron Donald and Leonard Floyd to form one of the most frightening pass rushing groups in the NFL. They’re also thin in the secondary, with cornerbacks Darious Wiliams (hand) and Dont’e Deayon (undisclosed) both questionable.

The home side is also dinged up, particularly in the secondary. Corners Jimmy Ward (quadriceps) and Josh Norman (ribs) are questionable, while Dre Kirkpatrick (ankle) and safety Tavon Wilson (foot) are already out.

Their offensive line took a hit when tackle Mike McGlinchey (quadriceps) was placed on injured reserve. Daniel Brunskill slots into that position and will be tested heavily Monday night.

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Rams and 49ers’ Recent Results

Los Angeles disappointed in a Week 9 primetime showdown with the Tennessee Titans, losing 28-16.

The Titans’ defense forced Matthew Stafford into interceptions on two straight passes, the first setting the Titans up inside the Rams’ 10, and the second one a quick-six. LA was down 21-3 before the two-minute warning in the first half, and they never recovered.

As for the 49ers, they were run over by the Cardinals at home last week 31-17, despite the fact the Cardinals had to go with Colt McCoy at QB for the injured Kyler Murray.

The good news is 49ers’ QB Jimmy Garoppolo looks as good as he has all year. He posted his second straight 300-yard passing game and 100+ rating, a feat he hasn’t accomplished since 2017.

Jimmy G has yet to lose to the Rams in his career, going 4-0, despite throwing five interceptions across those games.

Rams vs 49ers Trends

Even with that dud in Week 9, LA boasts the 4th-ranked NFL offense, averaging 29 points a game (5th). They also have the NFL’s leading receiver in Cooper Kupp, who leads the league with 74 catches, 1,109 yards and 10 TD’s in nine games.

Defensively, they’re sitting 12th, ranking seventh against the run, but they’ve been susceptible to the pass, ranking just 17th. The hope is Miller adds more chaos upfront, forcing coordinators to pick a 1-on-1 poison against a unit that already leads the NFL in sacks with 28.

The 49ers have been dreadful at home, having lost four straight to open the season for the first time since 1982. They’re just 1-11 at Levi’s over the last two seasons, with the lone win coming Oct 18 last year, against the Rams.

Meanwhile, Los Angeles has started the year 4-0 on the road, limiting teams to 18.5 points, while averaging 32.3 points themselves.

This is the first time all season the Rams will enter a contest as the road underdog. San Francisco, meanwhile, is 0-4 ATS as a home favorite, one of nine teams in the NFL yet to register a win as a home betting favorite against the spread.

What’s the Best Bet?

Usually, it would be easy to discount previous matchups between these two sides, especially with the myriad of moves the Rams have made in their perpetual quest to bolster the roster.

However, Stafford looked shaky against the Titans last time out, and the 49ers who boast the 8th-best defense, including a fourth in pass defense, could throw in some confusing wrinkles against the veteran QB like the Titans did.

Throw in the division rivalry, and this is a tough one to pin down. I think the Rams are the superior team, and they take the win, but it might be closer than that 3.5-point spread.

Pick: Rams ML (1.5 units to win 1.34 units )